Clotilde Hesme was born on July 14, 1979, in Troyes, Aube, France. She comes from a family involved in the arts; her siblings include actors Annelise Hesme and Élodie Hesme. She received formal training in acting at the Conservatoire National Supérieur d’Art Dramatique in Paris.
Hesme began her professional acting career in the early 2000s, quickly establishing herself as a versatile performer in both film and television. She has worked with prominent directors and appeared in a diverse range of roles, showcasing her ability to portray complex and nuanced characters.
Hesme has gained recognition for her performances in several critically acclaimed films. Her breakthrough role came with Les Chansons d’amour (Love Songs, 2007), directed by Christophe Honoré. She won the César Award for Most Promising Actress in 2012 for her role in Angèle et Tony (Angèle and Tony, 2010), directed by Alix Delaporte.
She is also known for her role in the television series Les Revenants (The Returned, 2012-2015), where she played Adèle Vergier, a significant character in the internationally acclaimed supernatural drama. In 2021, she played Juliette in the Netflix series Lupin.